GNB3 (G protein subunit beta 3)

2006-10-01  

Identity

HGNC
GNB3
LOCATION
12p13.31
LOCUSID
2784
ALIAS
CSNB1H
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2784
MIM: 139130
HGNC: 4400
Ensembl: ENSG00000111664

Variants:

dbSNP: 2784
ClinVar: 2784
TCGA: ENSG00000111664
COSMIC: GNB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111664ENST00000229264P16520
ENSG00000111664ENST00000229264F1T0G5
ENSG00000111664ENST00000435982E9PCP0
ENSG00000111664ENST00000537035F5H0S8
ENSG00000111664ENST00000539127F5GZN8
ENSG00000111664ENST00000541257F5H8J8
ENSG00000111664ENST00000541978F5H100

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cholinergic synapseKEGGhsa04725
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Presynaptic function of Kainate receptorsREACTOMER-HSA-500657
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsREACTOMER-HSA-997272
Potassium ChannelsREACTOMER-HSA-1296071
Inwardly rectifying K+ channelsREACTOMER-HSA-1296065
G protein gated Potassium channelsREACTOMER-HSA-1296059
Activation of G protein gated Potassium channelsREACTOMER-HSA-1296041
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Prostacyclin signalling through prostacyclin receptorREACTOMER-HSA-392851
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
G beta:gamma signalling through PLC betaREACTOMER-HSA-418217
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD19193342
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD18551043
PA134971947P2RY12GenePathwayassociated20938371
PA164712535Beta Blocking AgentsChemicalClinicalAnnotationassociated20860462
PA164713347Thiazides, plainChemicalClinicalAnnotationassociatedPD19247266
PA164741137ADCY3GenePathwayassociated20938371
PA166176017hydralazine / isosorbide dinitrateChemicalClinicalAnnotationassociatedPD25306451
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA32868P2RY1GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA33393PLCG2GenePathwayassociated20938371
PA348TBXA2RGenePathwayassociated20938371
PA443742Cluster HeadacheDiseaseClinicalAnnotationassociatedPD17361120
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD19247266
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD25306451
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD18551043
PA444606Erectile DysfunctionDiseaseClinicalAnnotationassociatedPD12576843
PA444797Liver CirrhosisDiseaseClinicalAnnotationassociatedPD12844135, 20833658
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD18551043
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD19303909
PA445131ObesityDiseaseClinicalAnnotationassociatedPD12893983
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19193342
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD20235788
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD20826553, 23733030, 30324302
PA448499atenololChemicalClinicalAnnotationassociatedPD20235788
PA448682bumetanideChemicalClinicalAnnotationassociatedPD20877298
PA449051clonidineChemicalClinicalAnnotationassociatedPD12844135, 20833658
PA449719furosemideChemicalClinicalAnnotationassociatedPD20877298
PA450401methadoneChemicalClinicalAnnotationassociatedPD19303909
PA450657nortriptylineChemicalClinicalAnnotationassociatedPD20826553
PA450688olanzapineChemicalClinicalAnnotationassociatedPD19193342
PA451333sertralineChemicalClinicalAnnotationassociatedPD30324302
PA451344sibutramineChemicalClinicalAnnotationassociatedPD12893983
PA451346sildenafilChemicalClinicalAnnotationassociatedPD12576843
PA451566sumatriptanChemicalClinicalAnnotationassociatedPD17361120
PA451605telmisartanChemicalClinicalAnnotationassociatedPD
PA451733torasemideChemicalClinicalAnnotationassociatedPD20877298
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD23733030

References

Pubmed IDYearTitleCitations
379976342024Association of GNB3, ACE polymorphisms with POAG and NTG.0
379976342024Association of GNB3, ACE polymorphisms with POAG and NTG.0
381264452023G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension.1
381264452023G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension.1
353739322022Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.2
354890512022Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension.1
353739322022Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.2
354890512022Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension.1
333682052021Meta-analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre-eclampsia.1
333682052021Meta-analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre-eclampsia.1
317689452020Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.5
323919162020Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics.3
317689452020Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.5
323919162020Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics.3
302537062019Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.1

Citation

Dessen P

GNB3 (G protein subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43286