HUNK (hormonally up-regulated Neu-associated kinase)

2006-10-01  

Identity

HGNC
HUNK
LOCATION
21q22.11
LOCUSID
30811
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 30811
MIM: 606532
HGNC: 13326
Ensembl: ENSG00000142149

Variants:

dbSNP: 30811
ClinVar: 30811
TCGA: ENSG00000142149
COSMIC: HUNK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142149ENST00000270112P57058
ENSG00000142149ENST00000430354H7C3H0
ENSG00000142149ENST00000439107H7C2X2

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380711092024HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.0
380711092024HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.0
371937112023HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.1
371937112023HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.1
315979542020HUNK phosphorylates EGFR to regulate breast cancer metastasis.18
315979542020HUNK phosphorylates EGFR to regulate breast cancer metastasis.18
317523452019HUNK Phosphorylates Rubicon to Support Autophagy.7
317523452019HUNK Phosphorylates Rubicon to Support Autophagy.7
281897832017Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.4
281897832017Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.4
255159312015Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.15
255159312015Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.15
213938592011Hunk is required for HER2/neu-induced mammary tumorigenesis.20
213938592011Hunk is required for HER2/neu-induced mammary tumorigenesis.20
201337592010HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.23

Citation

Dessen P

HUNK (hormonally up-regulated Neu-associated kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43311