Identity
HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
IKK-E,IKK-i,IKKE,IKKI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9641
MIM: 605048
HGNC: 14552
Ensembl: ENSG00000263528
Variants:
dbSNP: 9641
ClinVar: 9641
TCGA: ENSG00000263528
COSMIC: IKBKE
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131301952 | gefitinib | Chemical | ClinicalAnnotation | associated | PD | 31664190 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 31664190 | |
| PA443899 | Diarrhea | Disease | ClinicalAnnotation | associated | PD | 31664190 | |
| PA444109 | Exanthema | Disease | ClinicalAnnotation | associated | PD | 31664190 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36530063 | 2023 | Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models. | 0 |
| 36788451 | 2023 | Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response. | 1 |
| 36936901 | 2023 | Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency. | 3 |
| 37573607 | 2023 | IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma. | 0 |
| 36530063 | 2023 | Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models. | 0 |
| 36788451 | 2023 | Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response. | 1 |
| 36936901 | 2023 | Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency. | 3 |
| 37573607 | 2023 | IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma. | 0 |
| 34741724 | 2022 | Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation. | 1 |
| 35066576 | 2022 | IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. | 10 |
| 35930382 | 2022 | IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus. | 0 |
| 34741724 | 2022 | Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation. | 1 |
| 35066576 | 2022 | IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. | 10 |
| 35930382 | 2022 | IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus. | 0 |
| 33246224 | 2021 | miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKε. | 12 |
Citation
Dessen P
IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43315/ikbke
