IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

2006-10-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
IKK-E,IKK-i,IKKE,IKKI
FUSION GENES

Other Information

Locus ID:

NCBI: 9641
MIM: 605048
HGNC: 14552
Ensembl: ENSG00000263528

Variants:

dbSNP: 9641
ClinVar: 9641
TCGA: ENSG00000263528
COSMIC: IKBKE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000263528ENST00000578328A0A075B7B4
ENSG00000263528ENST00000579827A0A075B7D5
ENSG00000263528ENST00000581977Q14164
ENSG00000263528ENST00000584998Q14164
ENSG00000263528ENST00000605726A0A075B7C7

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD31664190
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD31664190
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD31664190
PA444109ExanthemaDiseaseClinicalAnnotationassociatedPD31664190

References

Pubmed IDYearTitleCitations
365300632023Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models.0
367884512023Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response.1
369369012023Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.3
375736072023IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma.0
365300632023Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models.0
367884512023Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response.1
369369012023Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.3
375736072023IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma.0
347417242022Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation.1
350665762022IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis.10
359303822022IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus.0
347417242022Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation.1
350665762022IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis.10
359303822022IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus.0
332462242021miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKε.12

Citation

Dessen P

IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43315/img/js/meetings/