ITSN2 (intersectin 2)

2006-10-01 Affiliation

Identity

HGNC

ITSN2

LOCATION

2p23.3

LOCUSID

50618

ALIAS

PRO2015,SH3D1B,SH3P18,SWA,SWAP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50618
MIM: 604464
HGNC: 6184
Ensembl: ENSG00000198399

Variants:

dbSNP: 50618
ClinVar: 50618
TCGA: ENSG00000198399
COSMIC: ITSN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198399	ENST00000355123	Q9NZM3
ENSG00000198399	ENST00000361999	Q9NZM3
ENSG00000198399	ENST00000406921	Q9NZM3
ENSG00000198399	ENST00000412011	E7EPJ2
ENSG00000198399	ENST00000416160	H7BZD4
ENSG00000198399	ENST00000427234	H7C0L8
ENSG00000198399	ENST00000443927	F8W719
ENSG00000198399	ENST00000449392	H7C3E2
ENSG00000198399	ENST00000622089	A0A087WVF7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28161632	2017	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	1
28161632	2017	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	1
26633357	2015	ITSN2L Interacts with and Negatively Regulates RABEP1.	3
26633357	2015	ITSN2L Interacts with and Negatively Regulates RABEP1.	3
23274495	2013	Crystal structure of human Intersectin-2L C2 domain.	1
23936226	2013	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	7
23274495	2013	Crystal structure of human Intersectin-2L C2 domain.	1
23936226	2013	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	7
22449706	2012	Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.	6
22449706	2012	Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.	6
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0
19622753	2009	Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.	24
19622753	2009	Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.	24
17390067	2007	Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.	4

Citation

Dessen P

ITSN2 (intersectin 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43330/css/lib/cancer-prone-explorer/favicon/manifest.json