Identity
HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
ASK2,MAPKKK6,MEKK6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9064
MIM: 604468
HGNC: 6858
Ensembl: ENSG00000142733
Variants:
dbSNP: 9064
ClinVar: 9064
TCGA: ENSG00000142733
COSMIC: MAP3K6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000142733 | ENST00000357582 | O95382 |
| ENSG00000142733 | ENST00000374040 | O95382 |
| ENSG00000142733 | ENST00000486046 | H0Y8A3 |
| ENSG00000142733 | ENST00000659880 | A0A590UJN3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32156783 | 2020 | Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases. | 9 |
| 32156783 | 2020 | Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases. | 9 |
| 29330337 | 2018 | Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility. | 17 |
| 29330337 | 2018 | Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility. | 17 |
| 26243192 | 2015 | The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. | 10 |
| 26243192 | 2015 | The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. | 10 |
| 25340522 | 2014 | Germline mutations in MAP3K6 are associated with familial gastric cancer. | 29 |
| 25340522 | 2014 | Germline mutations in MAP3K6 are associated with familial gastric cancer. | 29 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19246638 | 2009 | Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. | 19 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19246638 | 2009 | Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. | 19 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 18327563 | 2008 | ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. | 18 |
Citation
Dessen P
MAP3K6 (mitogen-activated protein kinase kinase kinase 6)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43344/map3k6
