NEK11 (NIMA related kinase 11)

2006-10-01 Affiliation

Identity

HGNC

NEK11

LOCATION

3q22.1

LOCUSID

79858

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79858
MIM: 609779
HGNC: 18593
Ensembl: ENSG00000114670

Variants:

dbSNP: 79858
ClinVar: 79858
TCGA: ENSG00000114670
COSMIC: NEK11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114670	ENST00000356918	Q8NG66
ENSG00000114670	ENST00000383366	Q8NG66
ENSG00000114670	ENST00000507910	Q8NG66
ENSG00000114670	ENST00000508196	Q8NG66
ENSG00000114670	ENST00000510474	D6RGV6
ENSG00000114670	ENST00000510688	Q8NG66
ENSG00000114670	ENST00000510769	E9PHI8
ENSG00000114670	ENST00000511262	Q8NG66
ENSG00000114670	ENST00000514915	D6RJF7
ENSG00000114670	ENST00000602792	A0A075B7B3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31704778	2020	NEK11 as a candidate high-penetrance melanoma susceptibility gene.	6
32034166	2020	Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.	6
31704778	2020	NEK11 as a candidate high-penetrance melanoma susceptibility gene.	6
32034166	2020	Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.	6
26501353	2015	Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.	12
26501353	2015	Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.	12
24969318	2014	Downregulation of NEK11 is associated with drug resistance in ovarian cancer.	8
24969318	2014	Downregulation of NEK11 is associated with drug resistance in ovarian cancer.	8
20090422	2010	NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.	20
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20090422	2010	NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.	20
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19734889	2009	NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.	66
19734889	2009	NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.	66
18519826	2008	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	145

Citation

Dessen P

NEK11 (NIMA related kinase 11)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43371/case-report-explorer/haematological-explorer/gene-fusions-explorer/