Identity
HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
HsPK21,NEK2A,NLK1,PPP1R111,RP67
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4751
MIM: 604043
HGNC: 7745
Ensembl: ENSG00000117650
Variants:
dbSNP: 4751
ClinVar: 4751
TCGA: ENSG00000117650
COSMIC: NEK2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117650 | ENST00000366998 | P51955 |
| ENSG00000117650 | ENST00000366999 | P51955 |
| ENSG00000117650 | ENST00000540251 | F6U4U2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38182898 | 2024 | Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers. | 0 |
| 38493150 | 2024 | Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction. | 0 |
| 38721812 | 2024 | Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis. | 0 |
| 38764296 | 2024 | NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells. | 0 |
| 38795132 | 2024 | NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1. | 0 |
| 38182898 | 2024 | Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers. | 0 |
| 38493150 | 2024 | Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction. | 0 |
| 38721812 | 2024 | Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis. | 0 |
| 38764296 | 2024 | NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells. | 0 |
| 38795132 | 2024 | NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1. | 0 |
| 36370999 | 2023 | NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis. | 1 |
| 36738674 | 2023 | Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer. | 2 |
| 38494974 | 2023 | [Expression and clinical significance of NEK2 and EMT related molecules in oral squamous cell carcinoma]. | 0 |
| 36370999 | 2023 | NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis. | 1 |
| 36738674 | 2023 | Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer. | 2 |
Citation
Dessen P
NEK2 (NIMA related kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43372/nek2
