NEK6 (NIMA related kinase 6)

2006-10-01  

Identity

HGNC
NEK6
LOCATION
9q33.3
LOCUSID
10783
ALIAS
SID6-1512
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10783
MIM: 604884
HGNC: 7749
Ensembl: ENSG00000119408

Variants:

dbSNP: 10783
ClinVar: 10783
TCGA: ENSG00000119408
COSMIC: NEK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119408ENST00000320246Q9HC98
ENSG00000119408ENST00000320246A0A024R8A6
ENSG00000119408ENST00000373596Q5TBG1
ENSG00000119408ENST00000373600Q9HC98
ENSG00000119408ENST00000373603Q9HC98
ENSG00000119408ENST00000373603A0A024R8A6
ENSG00000119408ENST00000394199Q9HC98
ENSG00000119408ENST00000422297Q5TBH2
ENSG00000119408ENST00000423785Q5TBG4
ENSG00000119408ENST00000425237Q5TBH1
ENSG00000119408ENST00000444973Q5TBG7
ENSG00000119408ENST00000447379Q5TBG2
ENSG00000119408ENST00000454453Q5TBH0
ENSG00000119408ENST00000539416Q9HC98
ENSG00000119408ENST00000540326Q9HC98
ENSG00000119408ENST00000545174Q9HC98
ENSG00000119408ENST00000545174A0A024R8A6
ENSG00000119408ENST00000546191Q9HC98
ENSG00000119408ENST00000546191A0A024R8A6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359934412023CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.10
366721912023NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells.4
359934412023CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.10
366721912023NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells.4
346439692022NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.1
358984552022Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.2
346439692022NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.1
358984552022Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.2
314097572019Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.18
314097572019Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.18
301539582018Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer.17
302078692018Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.52
301539582018Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer.17
302078692018Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.52
278993812017Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.17

Citation

Dessen P

NEK6 (NIMA related kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43374