NGEF (neuronal guanine nucleotide exchange factor)

2006-10-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
ARHGEF27,EPHEXIN
FUSION GENES

Other Information

Locus ID:

NCBI: 25791
MIM: 605991
HGNC: 7807
Ensembl: ENSG00000066248

Variants:

dbSNP: 25791
ClinVar: 25791
TCGA: ENSG00000066248
COSMIC: NGEF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066248ENST00000264051Q8N5V2
ENSG00000066248ENST00000373552Q8N5V2
ENSG00000066248ENST00000409079Q8N5V2
ENSG00000066248ENST00000414326H7C2C2
ENSG00000066248ENST00000416114C9JTV7
ENSG00000066248ENST00000424488H7BZ39

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
347118172021Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation.3
347118172021Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation.3
263404332015A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.9
263404332015A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.9
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
177027452007Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.20
177027452007Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.20

Citation

Dessen P

NGEF (neuronal guanine nucleotide exchange factor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43378/ngef