PAK3 (p21 (RAC1) activated kinase 3)

2006-10-01  

Identity

HGNC
PAK3
LOCATION
Xq23
LOCUSID
5063
ALIAS
ARA,MRX30,MRX47,OPHN3,PAK-3,PAK3beta,bPAK,beta-PAK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5063
MIM: 300142
HGNC: 8592
Ensembl: ENSG00000077264

Variants:

dbSNP: 5063
ClinVar: 5063
TCGA: ENSG00000077264
COSMIC: PAK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077264ENST00000262836O75914
ENSG00000077264ENST00000360648O75914
ENSG00000077264ENST00000372007O75914
ENSG00000077264ENST00000372010O75914
ENSG00000077264ENST00000417227O75914
ENSG00000077264ENST00000425146O75914
ENSG00000077264ENST00000429193B1AKS5
ENSG00000077264ENST00000446737O75914
ENSG00000077264ENST00000518291O75914
ENSG00000077264ENST00000519681O75914
ENSG00000077264ENST00000620137A0A087X294

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
T cell receptor signaling pathwayKEGGko04660
Regulation of actin cytoskeletonKEGGko04810
Renal cell carcinomaKEGGko05211
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
T cell receptor signaling pathwayKEGGhsa04660
Regulation of actin cytoskeletonKEGGhsa04810
Renal cell carcinomaKEGGhsa05211
Ras signaling pathwayKEGGhsa04014
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
CD28 dependent Vav1 pathwayREACTOMER-HSA-389359
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PAKsREACTOMER-HSA-5627123
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343810462021Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.23
345505322021PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.3
343810462021Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.23
345505322021PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.3
308907652020Prognostic significance of PAK family kinases in acute myeloid leukemia.11
314109262020Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.23
316782162020Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.3
318437062020PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.10
318979272020Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.6
319430582020The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.7
320509182020Novel PAK3 gene missense variant associated with two Chinese siblings with intellectual disability: a case report.6
308907652020Prognostic significance of PAK family kinases in acute myeloid leukemia.11
314109262020Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.23
316782162020Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.3
318437062020PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.10

Citation

Dessen P

PAK3 (p21 (RAC1) activated kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43392