CDK18 (cyclin dependent kinase 18)

2006-10-01  

Identity

HGNC
CDK18
LOCATION
1q32.1
LOCUSID
5129
ALIAS
PCTAIRE,PCTAIRE3,PCTK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5129
MIM: 169190
HGNC: 8751
Ensembl: ENSG00000117266

Variants:

dbSNP: 5129
ClinVar: 5129
TCGA: ENSG00000117266
COSMIC: CDK18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117266ENST00000360066Q07002
ENSG00000117266ENST00000360066A0A024R996
ENSG00000117266ENST00000419301A0A0A0MSJ6
ENSG00000117266ENST00000429964Q07002
ENSG00000117266ENST00000429964A0A024R996
ENSG00000117266ENST00000443813D6R9B0
ENSG00000117266ENST00000462976D6R9X1
ENSG00000117266ENST00000478560D6RA44
ENSG00000117266ENST00000504648D6R9X1
ENSG00000117266ENST00000506215D6RGH0
ENSG00000117266ENST00000506784Q07002
ENSG00000117266ENST00000506784A0A024R980
ENSG00000117266ENST00000512922D6R9X1
ENSG00000117266ENST00000515494D6R9X1

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366021252023Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.1
366021252023Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.1
321643292020Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.11
321643292020Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.11
312669512019Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.53
312669512019Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.53
268857532016Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.16
273820662016Human CDK18 promotes replication stress signaling and genome stability.28
268857532016Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.16
273820662016Human CDK18 promotes replication stress signaling and genome stability.28
167661952006The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.15
167661952006The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.15
150199842004Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.0
150199842004Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.0

Citation

Dessen P

CDK18 (cyclin dependent kinase 18)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43398/gene-fusions-explorer/css/cancer-prone-explorer/