INPP5J (inositol polyphosphate-5-phosphatase J)

2006-10-01  

Identity

HGNC
INPP5J
LOCATION
22q12.2
LOCUSID
27124
ALIAS
INPP5,PIB5PA,PIPP

Other Information

Locus ID:

NCBI: 27124
MIM: 606481
HGNC: 8956
Ensembl: ENSG00000185133

Variants:

dbSNP: 27124
ClinVar: 27124
TCGA: ENSG00000185133
COSMIC: INPP5J

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185133ENST00000331075Q15735
ENSG00000185133ENST00000400294Q15735
ENSG00000185133ENST00000401755B5MBZ3
ENSG00000185133ENST00000402238B5MCL8
ENSG00000185133ENST00000404390Q15735
ENSG00000185133ENST00000404453B5MBZ3
ENSG00000185133ENST00000405300Q15735
ENSG00000185133ENST00000412277B4DF95
ENSG00000185133ENST00000412985C9K0M5
ENSG00000185133ENST00000420017C9J0H5
ENSG00000185133ENST00000620191A0A087WVS7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGhsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGM00131
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204
Synthesis of IP2, IP, and Ins in the cytosolREACTOMER-HSA-1855183
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499

References

Pubmed IDYearTitleCitations
262675332015The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.65
262822172015MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.22
262675332015The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.65
262822172015MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.22
250991962014miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.35
250991962014miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.35
234435362013PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.36
234435362013PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.36

Citation

Dessen P

INPP5J (inositol polyphosphate-5-phosphatase J)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43409/inpp5j