Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 30849
MIM: 602610
HGNC: 8982
Ensembl: ENSG00000196455
Variants:
dbSNP: 30849
ClinVar: 30849
TCGA: ENSG00000196455
COSMIC: PIK3R4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196455 | ENST00000356763 | Q99570 |
| ENSG00000196455 | ENST00000507330 | D6RBB7 |
| ENSG00000196455 | ENST00000508273 | D6RJ98 |
| ENSG00000196455 | ENST00000512430 | D6RAC3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34121209 | 2021 | Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy. | 19 |
| 34121209 | 2021 | Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy. | 19 |
| 29311744 | 2018 | Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. | 23 |
| 29311744 | 2018 | Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. | 23 |
| 28102838 | 2017 | Autophagy dysregulation in Danon disease. | 34 |
| 28102838 | 2017 | Autophagy dysregulation in Danon disease. | 34 |
| 27882921 | 2016 | A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. | 34 |
| 27882921 | 2016 | A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. | 34 |
| 25840748 | 2015 | High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. | 10 |
| 25840748 | 2015 | High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. | 10 |
| 20643123 | 2010 | A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. | 99 |
| 20643123 | 2010 | A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. | 99 |
| 18957027 | 2009 | hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. | 51 |
| 18957027 | 2009 | hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. | 51 |
Citation
Dessen P
PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43410/pik3r4
