POLE4 (DNA polymerase epsilon 4, accessory subunit)

2006-10-01  

Identity

HGNC
LOCATION
2p12
LOCUSID
ALIAS
YHHQ1,p12
FUSION GENES

Other Information

Locus ID:

NCBI: 56655
MIM: 607269
HGNC: 18755
Ensembl: ENSG00000115350

Variants:

dbSNP: 56655
ClinVar: 56655
TCGA: ENSG00000115350
COSMIC: POLE4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115350ENST00000483063Q9NR33

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Base excision repairKEGGko03410
Nucleotide excision repairKEGGko03420
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Base excision repairKEGGhsa03410
Nucleotide excision repairKEGGhsa03420
Metabolic pathwaysKEGGhsa01100
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
DNA polymerase epsilon complexKEGGhsa_M00263
DNA polymerase epsilon complexKEGGM00263
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA replication initiationREACTOMER-HSA-68952
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Telomere C-strand synthesis initiationREACTOMER-HSA-174430
DNA ReplicationREACTOMER-HSA-69306
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
302175582018POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.61
302175582018POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.61

Citation

Dessen P

POLE4 (DNA polymerase epsilon 4, accessory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43419/gene-explorer/favicon/css/lib/bootstrap.min.css