POLM (DNA polymerase mu)

2006-10-01  

Identity

HGNC
POLM
LOCATION
7p13
LOCUSID
27434
ALIAS
Pol

Other Information

Locus ID:

NCBI: 27434
MIM: 606344
HGNC: 9185
Ensembl: ENSG00000122678

Variants:

dbSNP: 27434
ClinVar: 27434
TCGA: ENSG00000122678
COSMIC: POLM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122678ENST00000242248Q9NP87
ENSG00000122678ENST00000335195Q9NP87
ENSG00000122678ENST00000395831Q9NP87
ENSG00000122678ENST00000414235C9JF34
ENSG00000122678ENST00000418926H7C2M2
ENSG00000122678ENST00000430942Q9H980
ENSG00000122678ENST00000434229F8WDE4
ENSG00000122678ENST00000435068F8WEJ1
ENSG00000122678ENST00000445616F8WB78
ENSG00000122678ENST00000452049C9J222
ENSG00000122678ENST00000458246Q6PIY2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Non-homologous end-joiningKEGGko03450
Non-homologous end-joiningKEGGhsa03450
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
336005642021DNA Polymerase and dRP-lyase activities of polymorphic variants of human Pol ι.0
341452982021Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.4
336005642021DNA Polymerase and dRP-lyase activities of polymorphic variants of human Pol ι.0
341452982021Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.4
330872692020DNA polymerase mu: An inflexible scaffold for substrate flexibility.2
330872692020DNA polymerase mu: An inflexible scaffold for substrate flexibility.2
303100682018Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate.13
303100682018Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate.13
289110972017Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.23
289734412017Polμ tumor variants decrease the efficiency and accuracy of NHEJ.4
289110972017Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.23
289734412017Polμ tumor variants decrease the efficiency and accuracy of NHEJ.4
262403732015Creative template-dependent synthesis by human polymerase mu.20
262403732015Creative template-dependent synthesis by human polymerase mu.20
244879592014Sustained active site rigidity during synthesis by human DNA polymerase μ.41

Citation

Dessen P

POLM (DNA polymerase mu)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43421/polm-(dna-polymerase-mu)