POLN (DNA polymerase nu)

2006-10-01  

Identity

HGNC
POLN
LOCATION
4p16.3
LOCUSID
353497
ALIAS
POL4P
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 353497
MIM: 610887
HGNC: 18870
Ensembl: ENSG00000130997

Variants:

dbSNP: 353497
ClinVar: 353497
TCGA: ENSG00000130997
COSMIC: POLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130997ENST00000382865Q7Z5Q5
ENSG00000130997ENST00000511098H0YA88
ENSG00000130997ENST00000511885Q7Z5Q5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
358156342022Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.1
361162132022Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.4
358156342022Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.1
361162132022Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.4
340888462021Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.10
344611012021DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.3
340888462021Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.10
344611012021DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.3
320988702020The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells.5
331750932020Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η.5
320988702020The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells.5
331750932020Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η.5
303689482019Crystallographic evidence for two-metal-ion catalysis in human pol η.9
307099152019Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η.9
308422612019Human DNA polymerase η has reverse transcriptase activity in cellular environments.20

Citation

Dessen P

POLN (DNA polymerase nu)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43422/haematological-explorer/gene-fusions-explorer/js/lib/popper.js