Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 353497
MIM: 610887
HGNC: 18870
Ensembl: ENSG00000130997
Variants:
dbSNP: 353497
ClinVar: 353497
TCGA: ENSG00000130997
COSMIC: POLN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000130997 | ENST00000382865 | Q7Z5Q5 |
| ENSG00000130997 | ENST00000511098 | H0YA88 |
| ENSG00000130997 | ENST00000511885 | Q7Z5Q5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Fanconi anemia pathway | KEGG | ko03460 |
| Fanconi anemia pathway | KEGG | hsa03460 |
| DNA Repair | REACTOME | R-HSA-73894 |
| Fanconi Anemia Pathway | REACTOME | R-HSA-6783310 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35815634 | 2022 | Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells. | 1 |
| 36116213 | 2022 | Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. | 4 |
| 35815634 | 2022 | Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells. | 1 |
| 36116213 | 2022 | Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. | 4 |
| 34088846 | 2021 | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. | 10 |
| 34461101 | 2021 | DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides. | 3 |
| 34088846 | 2021 | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. | 10 |
| 34461101 | 2021 | DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides. | 3 |
| 32098870 | 2020 | The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells. | 5 |
| 33175093 | 2020 | Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η. | 5 |
| 32098870 | 2020 | The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells. | 5 |
| 33175093 | 2020 | Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η. | 5 |
| 30368948 | 2019 | Crystallographic evidence for two-metal-ion catalysis in human pol η. | 9 |
| 30709915 | 2019 | Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η. | 9 |
| 30842261 | 2019 | Human DNA polymerase η has reverse transcriptase activity in cellular environments. | 20 |
Citation
Dessen P
POLN (DNA polymerase nu)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43422/poln
