PSME4 (proteasome activator subunit 4)

2006-10-01 Affiliation

Identity

HGNC

PSME4

LOCATION

2p16.2

LOCUSID

23198

ALIAS

PA200

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23198
MIM: 607705
HGNC: 20635
Ensembl: ENSG00000068878

Variants:

dbSNP: 23198
ClinVar: 23198
TCGA: ENSG00000068878
COSMIC: PSME4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000068878	ENST00000389993	F8WBH5
ENSG00000068878	ENST00000404125	Q14997

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Proteasome	KEGG	ko03050
Proteasome	KEGG	hsa03050
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Hh mutants abrogate ligand secretion	REACTOME	R-HSA-5387390
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	REACTOME	R-HSA-5362768
Disorders of transmembrane transporters	REACTOME	R-HSA-5619115
ABC transporter disorders	REACTOME	R-HSA-5619084
Defective CFTR causes cystic fibrosis	REACTOME	R-HSA-5678895
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Vif-mediated degradation of APOBEC3G	REACTOME	R-HSA-180585
Vpu mediated degradation of CD4	REACTOME	R-HSA-180534
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Cross-presentation of soluble exogenous antigens (endosomes)	REACTOME	R-HSA-1236978
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Regulation of RAS by GAPs	REACTOME	R-HSA-5658442
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signaling	REACTOME	R-HSA-5607761
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
NIK-->noncanonical NF-kB signaling	REACTOME	R-HSA-5676590
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Degradation of DVL	REACTOME	R-HSA-4641258
Degradation of AXIN	REACTOME	R-HSA-4641257
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog ligand biogenesis	REACTOME	R-HSA-5358346
Hedgehog 'off' state	REACTOME	R-HSA-5610787
GLI3 is processed to GLI3R by the proteasome	REACTOME	R-HSA-5610785
Degradation of GLI2 by the proteasome	REACTOME	R-HSA-5610783
Degradation of GLI1 by the proteasome	REACTOME	R-HSA-5610780
Hedgehog 'on' state	REACTOME	R-HSA-5632684
Gene Expression	REACTOME	R-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G1/S DNA Damage Checkpoints	REACTOME	R-HSA-69615
p53-Dependent G1/S DNA damage checkpoint	REACTOME	R-HSA-69580
p53-Dependent G1 DNA Damage Response	REACTOME	R-HSA-69563
Stabilization of p53	REACTOME	R-HSA-69541
Autodegradation of the E3 ubiquitin ligase COP1	REACTOME	R-HSA-349425
p53-Independent G1/S DNA damage checkpoint	REACTOME	R-HSA-69613
p53-Independent DNA Damage Response	REACTOME	R-HSA-69610
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	REACTOME	R-HSA-69601
G2/M Checkpoints	REACTOME	R-HSA-69481
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
S Phase	REACTOME	R-HSA-69242
Synthesis of DNA	REACTOME	R-HSA-69239
Switching of origins to a post-replicative state	REACTOME	R-HSA-69052
Orc1 removal from chromatin	REACTOME	R-HSA-68949
CDK-mediated phosphorylation and removal of Cdc6	REACTOME	R-HSA-69017
Ubiquitin-dependent degradation of Cyclin D	REACTOME	R-HSA-75815
Ubiquitin-dependent degradation of Cyclin D1	REACTOME	R-HSA-69229
Regulation of DNA replication	REACTOME	R-HSA-69304
Removal of licensing factors from origins	REACTOME	R-HSA-69300
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
M Phase	REACTOME	R-HSA-68886
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
Assembly of the pre-replicative complex	REACTOME	R-HSA-68867
CDT1 association with the CDC6:ORC:origin complex	REACTOME	R-HSA-68827
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
SCF-beta-TrCP mediated degradation of Emi1	REACTOME	R-HSA-174113
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	REACTOME	R-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACTOME	R-HSA-174184
APC/C:Cdc20 mediated degradation of Securin	REACTOME	R-HSA-174154
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACTOME	R-HSA-174178
DNA Replication	REACTOME	R-HSA-69306
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Metabolism of polyamines	REACTOME	R-HSA-351202
Regulation of ornithine decarboxylase (ODC)	REACTOME	R-HSA-350562
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Regulation of Apoptosis	REACTOME	R-HSA-169911
Regulation of activated PAK-2p34 by proteasome mediated degradation	REACTOME	R-HSA-211733
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
The role of GTSE1 in G2/M progression after G2 checkpoint	REACTOME	R-HSA-8852276
Deubiquitination	REACTOME	R-HSA-5688426
UCH proteinases	REACTOME	R-HSA-5689603
Ub-specific processing proteases	REACTOME	R-HSA-5689880
RET signaling	REACTOME	R-HSA-8853659
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	REACTOME	R-HSA-8854050

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37217651	2023	The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.	6
37217651	2023	The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.	6
33562813	2021	Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.	4
33562813	2021	Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.	4
32368861	2020	The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.	7
33233776	2020	The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.	9
32368861	2020	The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.	7
33233776	2020	The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.	9
31473102	2019	Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes.	53
31645612	2019	Proteasome activator PA200 regulates myofibroblast differentiation.	9
31473102	2019	Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes.	53
31645612	2019	Proteasome activator PA200 regulates myofibroblast differentiation.	9
30104204	2018	DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.	31
30104204	2018	DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.	31
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78

Citation

Dessen P

PSME4 (proteasome activator subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43438/meetings/case-report-explorer/css/template-nav.css