RASGRP1 (RAS guanyl releasing protein 1)

2006-10-01 Affiliation

Identity

HGNC

RASGRP1

LOCATION

15q14

LOCUSID

10125

ALIAS

CALDAG-GEFI,CALDAG-GEFII,IMD64,RASGRP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10125
MIM: 603962
HGNC: 9878
Ensembl: ENSG00000172575

Variants:

dbSNP: 10125
ClinVar: 10125
TCGA: ENSG00000172575
COSMIC: RASGRP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172575	ENST00000310803	O95267
ENSG00000172575	ENST00000414708	O95267
ENSG00000172575	ENST00000450598	O95267
ENSG00000172575	ENST00000539159	F5H514
ENSG00000172575	ENST00000557875	H0YMT0
ENSG00000172575	ENST00000558164	O95267
ENSG00000172575	ENST00000558418	H0YN83
ENSG00000172575	ENST00000558432	H0YMF3
ENSG00000172575	ENST00000559830	O95267
ENSG00000172575	ENST00000560425	H0YNK9
ENSG00000172575	ENST00000560929	H0YKP8
ENSG00000172575	ENST00000561117	H0YNG8
ENSG00000172575	ENST00000561180	H0YKM0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
T cell receptor signaling pathway	KEGG	ko04660
MAPK signaling pathway	KEGG	hsa04010
T cell receptor signaling pathway	KEGG	hsa04660
Pathways in cancer	KEGG	hsa05200
Ras signaling pathway	KEGG	hsa04014
Platelet activation	KEGG	hsa04611
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of RAS in B cells	REACTOME	R-HSA-1169092
Rap1 signalling	REACTOME	R-HSA-392517
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
RET signaling	REACTOME	R-HSA-8853659

References

Pubmed ID	Year	Title	Citations
36675167	2023	A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.	4
36675167	2023	A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.	4
35204828	2022	Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients.	3
35204828	2022	Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients.	3
33065764	2021	Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.	9
33065764	2021	Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.	9
32612143	2020	Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.	15
32830401	2020	Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.	10
32612143	2020	Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.	15
32830401	2020	Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.	10
31120617	2019	RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.	8
31164884	2019	Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility.	9
31237864	2019	RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.	17
31120617	2019	RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.	8
31164884	2019	Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility.	9

Citation

Dessen P

RASGRP1 (RAS guanyl releasing protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43455/rasgrp1

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