RASGRP3 (RAS guanyl releasing protein 3)

2006-10-01  

Identity

HGNC
LOCATION
2p22.3
LOCUSID
ALIAS
GRP3
FUSION GENES

Other Information

Locus ID:

NCBI: 25780
MIM: 609531
HGNC: 14545
Ensembl: ENSG00000152689

Variants:

dbSNP: 25780
ClinVar: 25780
TCGA: ENSG00000152689
COSMIC: RASGRP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152689ENST00000402538Q8IV61
ENSG00000152689ENST00000403687Q8IV61
ENSG00000152689ENST00000419772H7C352
ENSG00000152689ENST00000423159C9JWP0
ENSG00000152689ENST00000425210C9JSS2
ENSG00000152689ENST00000437184C9K0P4
ENSG00000152689ENST00000442390C9J9C9
ENSG00000152689ENST00000444784C9IYA5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
B cell receptor signaling pathwayKEGGko04662
MAPK signaling pathwayKEGGhsa04010
B cell receptor signaling pathwayKEGGhsa04662
Pathways in cancerKEGGhsa05200
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
Activation of RAS in B cellsREACTOMER-HSA-1169092
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659

References

Pubmed IDYearTitleCitations
294616442018RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma.2
294616442018RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma.2
284861072017RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.80
288641152017RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.7
289121012017Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.1
290486432017Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma.2
284861072017RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.80
288641152017RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.7
289121012017Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.1
290486432017Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma.2
244189122014Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.6
247796812014Function of RasGRP3 in the formation and progression of human breast cancer.10
244189122014Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.6
247796812014Function of RasGRP3 in the formation and progression of human breast cancer.10
216028812011RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.20

Citation

Dessen P

RASGRP3 (RAS guanyl releasing protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43457/rasgrp3