Identity
HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
MSK2,RSK-B,S6K-alpha-4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8986
MIM: 603606
HGNC: 10433
Ensembl: ENSG00000162302
Variants:
dbSNP: 8986
ClinVar: 8986
TCGA: ENSG00000162302
COSMIC: RPS6KA4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162302 | ENST00000334205 | O75676 |
| ENSG00000162302 | ENST00000528057 | E9PJN1 |
| ENSG00000162302 | ENST00000528355 | E9PKU3 |
| ENSG00000162302 | ENST00000530504 | A0A0A6YYC0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36812480 | 2023 | Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states. | 3 |
| 37278562 | 2023 | Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival. | 1 |
| 37462338 | 2023 | Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses. | 0 |
| 36812480 | 2023 | Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states. | 3 |
| 37278562 | 2023 | Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival. | 1 |
| 37462338 | 2023 | Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses. | 0 |
| 34445361 | 2021 | Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction. | 1 |
| 34445361 | 2021 | Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction. | 1 |
| 28930610 | 2018 | RPS6KA4/MIR1237 and AURKC promoter regions are differentially methylated in Wilms' tumor. | 3 |
| 28930610 | 2018 | RPS6KA4/MIR1237 and AURKC promoter regions are differentially methylated in Wilms' tumor. | 3 |
| 26109721 | 2015 | Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. | 20 |
| 26109721 | 2015 | Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. | 20 |
| 24792438 | 2014 | Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes. | 11 |
| 24792438 | 2014 | Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes. | 11 |
| 23675462 | 2013 | Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. | 8 |
Citation
Dessen P
RPS6KA4 (ribosomal protein S6 kinase A4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43479/rps6ka4
