SCYL1 (SCY1 like pseudokinase 1)

2006-10-01  

Identity

HGNC
SCYL1
LOCATION
11q13.1
LOCUSID
57410
ALIAS
GKLP,HT019,NKTL,NTKL,P105,SCAR21,TAPK,TEIF,TRAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57410
MIM: 607982
HGNC: 14372
Ensembl: ENSG00000142186

Variants:

dbSNP: 57410
ClinVar: 57410
TCGA: ENSG00000142186
COSMIC: SCYL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142186ENST00000270176Q96KG9
ENSG00000142186ENST00000279270A0A0A0MQX4
ENSG00000142186ENST00000420247Q96KG9
ENSG00000142186ENST00000524944E9PS17
ENSG00000142186ENST00000525364E9PK59
ENSG00000142186ENST00000527009E9PPN3
ENSG00000142186ENST00000528545H0YDH0
ENSG00000142186ENST00000531601H0YCI6
ENSG00000142186ENST00000533862Q96KG9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362908212022Overexpression of SCYL1 Is Associated with Progression of Breast Cancer.1
362908212022Overexpression of SCYL1 Is Associated with Progression of Breast Cancer.1
334429272021SCYL1 disease and liver transplantation diagnosed by reanalysis of exome sequencing and deletion/duplication analysis of SCYL1.1
334429272021SCYL1 disease and liver transplantation diagnosed by reanalysis of exome sequencing and deletion/duplication analysis of SCYL1.1
321460382020Mutations in NBAS and SCYL1, genetic causes of recurrent liver failure in children: Three case reports and a literature review.8
325837412020SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.8
321460382020Mutations in NBAS and SCYL1, genetic causes of recurrent liver failure in children: Three case reports and a literature review.8
325837412020SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.8
302581222019Variant in SCYL1 gene causes aberrant splicing in a family with cerebellar ataxia, recurrent episodes of liver failure, and growth retardation.13
302581222019Variant in SCYL1 gene causes aberrant splicing in a family with cerebellar ataxia, recurrent episodes of liver failure, and growth retardation.13
294198182018SCYL1 variants cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN).24
294198182018SCYL1 variants cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN).24
285706642017SCYL1 does not regulate REST expression and turnover.6
285706642017SCYL1 does not regulate REST expression and turnover.6
255758112015Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility.9

Citation

Dessen P

SCYL1 (SCY1 like pseudokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43486