Identity
HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
LOH11CR1I,QIK,SIK-2,SNF1LK2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23235
MIM: 608973
HGNC: 21680
Ensembl: ENSG00000170145
Variants:
dbSNP: 23235
ClinVar: 23235
TCGA: ENSG00000170145
COSMIC: SIK2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000170145 | ENST00000304987 | Q9H0K1 |
| ENSG00000170145 | ENST00000304987 | A0A024R3G7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Glucagon signaling pathway | KEGG | hsa04922 |
| Glucagon signaling pathway | KEGG | ko04922 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37772720 | 2024 | SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective. | 0 |
| 37772720 | 2024 | SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective. | 0 |
| 36075517 | 2023 | SIK2 protects against renal tubular injury and the progression of diabetic kidney disease. | 3 |
| 37219665 | 2023 | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | 2 |
| 37608474 | 2023 | Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes. | 1 |
| 37966164 | 2023 | LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition. | 3 |
| 36075517 | 2023 | SIK2 protects against renal tubular injury and the progression of diabetic kidney disease. | 3 |
| 37219665 | 2023 | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | 2 |
| 37608474 | 2023 | Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes. | 1 |
| 37966164 | 2023 | LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition. | 3 |
| 34058059 | 2022 | SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. | 0 |
| 35277657 | 2022 | SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling. | 9 |
| 35278271 | 2022 | SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK. | 8 |
| 34058059 | 2022 | SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. | 0 |
| 35277657 | 2022 | SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling. | 9 |
Citation
Dessen P
SIK2 (salt inducible kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43497/sik2
