SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1)

2006-10-01  

Identity

HGNC
SRGAP1
LOCATION
12q14.2
LOCUSID
57522
ALIAS
ARHGAP13,NMTC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57522
MIM: 606523
HGNC: 17382
Ensembl: ENSG00000196935

Variants:

dbSNP: 57522
ClinVar: 57522
TCGA: ENSG00000196935
COSMIC: SRGAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196935ENST00000355086Q7Z6B7
ENSG00000196935ENST00000543397G5EA48
ENSG00000196935ENST00000631006G5EA48

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Inactivation of Cdc42 and RacREACTOMER-HSA-428543

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
339843632021Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.4
339843632021Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.4
291609052018Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.5
292341512018SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.21
291609052018Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.5
292341512018SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.21
279233832016srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.19
279233832016srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.19
260260802015MicroRNA-145 Promotes the Phenotype of Human Glioblastoma Cells Selected for Invasion.13
260267922015Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.35
260260802015MicroRNA-145 Promotes the Phenotype of Human Glioblastoma Cells Selected for Invasion.13
260267922015Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.35
251345342014Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.40
251509782014An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.47
251345342014Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.40

Citation

Dessen P

SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43502