ZRANB1 (zinc finger RANBP2-type containing 1)

2006-10-01 Affiliation

Identity

HGNC

ZRANB1

LOCATION

10q26.13

LOCUSID

54764

ALIAS

TRABID

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54764
MIM: 611749
HGNC: 18224
Ensembl: ENSG00000019995

Variants:

dbSNP: 54764
ClinVar: 54764
TCGA: ENSG00000019995
COSMIC: ZRANB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000019995	ENST00000359653	Q9UGI0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Deubiquitination	REACTOME	R-HSA-5688426
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37831441	2023	The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.	4
38099646	2023	Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.	0
37831441	2023	The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.	4
38099646	2023	Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.	0
34798260	2022	ZRANB1 enhances stem-cell-like features and accelerates tumor progression by regulating Sox9-mediated USP22/Wnt/β-catenin pathway in colorectal cancer.	11
35944360	2022	TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells.	2
34798260	2022	ZRANB1 enhances stem-cell-like features and accelerates tumor progression by regulating Sox9-mediated USP22/Wnt/β-catenin pathway in colorectal cancer.	11
35944360	2022	TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells.	2
33853758	2021	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	12
33853758	2021	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	12
29748601	2019	Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1.	23
29748601	2019	Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1.	23
29669287	2018	ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.	26
29669287	2018	ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.	26
22157957	2011	An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.	66

Citation

Dessen P

ZRANB1 (zinc finger RANBP2-type containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43561/js/tumors-explorer/