LPAR3 (lysophosphatidic acid receptor 3)

2007-02-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
EDG7,Edg-7,GPCR,HOFNH30,LP-A3,LPA3,RP4-678I3
FUSION GENES

Other Information

Locus ID:

NCBI: 23566
MIM: 605106
HGNC: 14298
Ensembl: ENSG00000171517

Variants:

dbSNP: 23566
ClinVar: 23566
TCGA: ENSG00000171517
COSMIC: LPAR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171517ENST00000370611Q9UBY5
ENSG00000171517ENST00000440886Q9UBY5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

References

Pubmed IDYearTitleCitations
389281962024Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites.0
389281962024Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites.0
364162362023LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.0
364162362023LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.0
333478622021Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA(2)) and LPA(3) in osteosarcoma cells.3
334060262021Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.3
333478622021Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA(2)) and LPA(3) in osteosarcoma cells.3
334060262021Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.3
317140042020Lysophosphatidic acid receptor LPA(3) prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.18
320066102020Effects of lysophosphatidic acid (LPA) receptor-2 (LPA(2)) and LPA(3) on the regulation of chemoresistance to anticancer drug in lung cancer cells.6
322960172020The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.29
317140042020Lysophosphatidic acid receptor LPA(3) prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.18
320066102020Effects of lysophosphatidic acid (LPA) receptor-2 (LPA(2)) and LPA(3) on the regulation of chemoresistance to anticancer drug in lung cancer cells.6
322960172020The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.29
302667532019miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3-Binding Domain to Regulate Wnt1.11

Citation

Dessen P

LPAR3 (lysophosphatidic acid receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43584/lpar3