GRM5 (glutamate metabotropic receptor 5)

2007-02-01  

Identity

HGNC
GRM5
LOCATION
11q14.2
LOCUSID
2915
ALIAS
GPRC1E,MGLUR5,PPP1R86,mGlu5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2915
MIM: 604102
HGNC: 4597
Ensembl: ENSG00000168959

Variants:

dbSNP: 2915
ClinVar: 2915
TCGA: ENSG00000168959
COSMIC: GRM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168959ENST00000305432P41594
ENSG00000168959ENST00000305447P41594
ENSG00000168959ENST00000393294A8MT20
ENSG00000168959ENST00000449371H7C223
ENSG00000168959ENST00000455756P41594

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Long-term potentiationKEGGko04720
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Long-term potentiationKEGGhsa04720
Huntington's diseaseKEGGhsa05016
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Neuronal SystemREACTOMER-HSA-112316
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

References

Pubmed IDYearTitleCitations
382170402024Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [(18)F]PSS232 PET/MRI study.1
383696902024Voltage tunes mGlu(5) receptor function, impacting synaptic transmission.1
386324032024Stepwise activation of a metabotropic glutamate receptor.0
388763172024Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.0
382170402024Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [(18)F]PSS232 PET/MRI study.1
383696902024Voltage tunes mGlu(5) receptor function, impacting synaptic transmission.1
386324032024Stepwise activation of a metabotropic glutamate receptor.0
388763172024Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.0
368423052023Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.0
374879482023Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.2
381463652023Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.1
368423052023Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.0
374879482023Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.2
381463652023Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.1
345162932022Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease.26

Citation

Dessen P

GRM5 (glutamate metabotropic receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43586/gene-fusions-explorer/favicon/apple-touch-icon.png