PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta)

2007-02-01  

Identity

HGNC
PPP2R2B
LOCATION
5q32
LOCUSID
5521
ALIAS
B55BETA,PP2AB55BETA,PP2ABBETA,PP2APR55B,PP2APR55BETA,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55BETA,SCA12
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5521
MIM: 604325
HGNC: 9305
Ensembl: ENSG00000156475

Variants:

dbSNP: 5521
ClinVar: 5521
TCGA: ENSG00000156475
COSMIC: PPP2R2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156475ENST00000336640Q00005
ENSG00000156475ENST00000394409Q00005
ENSG00000156475ENST00000394411Q00005
ENSG00000156475ENST00000394413Q00005
ENSG00000156475ENST00000394414Q00005
ENSG00000156475ENST00000453001Q00005
ENSG00000156475ENST00000504198Q00005
ENSG00000156475ENST00000504565E5RFC4
ENSG00000156475ENST00000508267D6RGF9
ENSG00000156475ENST00000508545Q00005
ENSG00000156475ENST00000512011D6RB57
ENSG00000156475ENST00000512639E9PCT7
ENSG00000156475ENST00000512984H0YA16
ENSG00000156475ENST00000515880D6RF04
ENSG00000156475ENST00000528601E9PCT7
ENSG00000156475ENST00000532154E9PCT7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384090852024Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway.1
384090852024Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway.1
377359232023Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.1
377359232023Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.1
317428922020Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma.13
332087502020EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.23
317428922020Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma.13
332087502020EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.23
313353202019PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.10
314949262019Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A.33
313353202019PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.10
314949262019Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A.33
292753622018Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.5
292753622018Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.5
278642672017Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B.21

Citation

Dessen P

PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43587