ADAM8 (ADAM metallopeptidase domain 8)

2007-02-01  

Identity

HGNC
LOCATION
10q26.3
LOCUSID
ALIAS
CD156,CD156a,MS2
FUSION GENES

Other Information

Locus ID:

NCBI: 101
MIM: 602267
HGNC: 215
Ensembl: ENSG00000151651

Variants:

dbSNP: 101
ClinVar: 101
TCGA: ENSG00000151651
COSMIC: ADAM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151651ENST00000415217P78325
ENSG00000151651ENST00000445355P78325
ENSG00000151651ENST00000485491P78325
ENSG00000151651ENST00000486609H0YMT6
ENSG00000151651ENST00000560135H0YKZ1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379929872024Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy.3
379929872024Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy.3
352160882022ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.7
352160882022ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9.7
333147202021Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells.9
335444722021ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis.16
338467722021TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells.5
333147202021Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells.9
335444722021ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis.16
338467722021TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells.5
329546492020A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-β/Smad2/3 signalling pathway.5
329546492020A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-β/Smad2/3 signalling pathway.5
308616162019Propofol inhibits pancreatic cancer proliferation and metastasis by up-regulating miR-328 and down-regulating ADAM8.20
313052942019ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis.2
313473252019A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer.7

Citation

Dessen P

ADAM8 (ADAM metallopeptidase domain 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43603/js/img/js/lib/popper.js