PABPC1 (poly(A) binding protein cytoplasmic 1)

2007-02-01  

Identity

HGNC
PABPC1
LOCATION
8q22.3
LOCUSID
26986
ALIAS
PAB1,PABP,PABP1,PABPC2,PABPL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26986
MIM: 604679
HGNC: 8554
Ensembl: ENSG00000070756

Variants:

dbSNP: 26986
ClinVar: 26986
TCGA: ENSG00000070756
COSMIC: PABPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070756ENST00000318607P11940
ENSG00000070756ENST00000318607A0A024R9C1
ENSG00000070756ENST00000517403H0YAW6
ENSG00000070756ENST00000517990H0YAS7
ENSG00000070756ENST00000518196E5RGH3
ENSG00000070756ENST00000518293H0YC10
ENSG00000070756ENST00000519004E7EQV3
ENSG00000070756ENST00000519100H0YAR2
ENSG00000070756ENST00000519363E5RJM8
ENSG00000070756ENST00000519622H0YAP2
ENSG00000070756ENST00000520142E5RH24
ENSG00000070756ENST00000520804E5RGC4
ENSG00000070756ENST00000520868H0YAS6
ENSG00000070756ENST00000521067E5RFD8
ENSG00000070756ENST00000521865E5RJB9
ENSG00000070756ENST00000522387E7ERJ7
ENSG00000070756ENST00000522658H0YB75
ENSG00000070756ENST00000522720E5RHG7
ENSG00000070756ENST00000523555H0YBN4
ENSG00000070756ENST00000523636H0YB86
ENSG00000070756ENST00000610907A0A087WTT1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNAREACTOMER-HSA-450408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381975342024BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.0
383661452024LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization.0
385324272024Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.1
381975342024BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.0
383661452024LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization.0
385324272024Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.1
375061502023PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression.2
379567712023A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.0
375061502023PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression.2
379567712023A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.0
350400032022Identification of putative genetic variants in major depressive disorder patients in Pakistan.2
350744822022PABP1 Drives the Selective Translation of Influenza A Virus mRNA.5
353463242022PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p.18
355111362022De novo variants in the PABP domain of PABPC1 lead to developmental delay.2
356407182022Structural Model of the Human BTG2-PABPC1 Complex by Combining Mutagenesis, NMR Chemical Shift Perturbation Data and Molecular Docking.3

Citation

Dessen P

PABPC1 (poly(A) binding protein cytoplasmic 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43613