IL7 (interleukin 7)

2007-02-01  

Identity

HGNC
IL7
LOCATION
8q21.13
LOCUSID
3574
ALIAS
IL-7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3574
MIM: 146660
HGNC: 6023
Ensembl: ENSG00000104432

Variants:

dbSNP: 3574
ClinVar: 3574
TCGA: ENSG00000104432
COSMIC: IL7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104432ENST00000263851P13232
ENSG00000104432ENST00000379113Q5FBX5
ENSG00000104432ENST00000518982Q5FBY3
ENSG00000104432ENST00000520215Q5FBY6
ENSG00000104432ENST00000520269P13232
ENSG00000104432ENST00000520317Q5FBY6
ENSG00000104432ENST00000541183A0A0A0MTG5
ENSG00000104432ENST00000639719Q5FBY3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-7 signalingREACTOMER-HSA-1266695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365038702023IL-7 and IL-7R in health and disease: An update through COVID times.1
366275282023Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren's syndrome.2
367485682023IL-7 germline variant: setting the stage for immune-related adverse events.1
373690822023IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.5
375664742023The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review.0
365038702023IL-7 and IL-7R in health and disease: An update through COVID times.1
366275282023Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren's syndrome.2
367485682023IL-7 germline variant: setting the stage for immune-related adverse events.1
373690822023IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.5
375664742023The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review.0
354055972022Association between IL-7 and primary Sjögren's syndrome: A single-center study and a systematic scoping review.1
356028892022LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis.1
358506402022Interleukin-7 regulates CD127 expression and promotes CD8(+) T cell activity in patients with primary cutaneous melanoma.0
359079232022IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study.1
360547462022IL-7 is expressed in malignant mesothelioma and has a prognostic value.1

Citation

Dessen P

IL7 (interleukin 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43614/haematological-explorer/favicon/js/web-card-_common.js