KIR2DL3 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3)

2012-01-01  

Identity

HGNC
KIR2DL3
LOCATION
19q13.42
LOCUSID
3804
ALIAS
CD158B2,CD158b,GL183,KIR-023GB,KIR-K7b,KIR-K7c,KIR2DL,KIR2DS5,KIRCL23,NKAT,NKAT2,NKAT2A,NKAT2B,p58

Other Information

Locus ID:

NCBI: 3804
MIM: 604938
HGNC: 6331
Ensembl: ENSG00000243772

Variants:

dbSNP: 3804
ClinVar: 3804
TCGA: ENSG00000243772
COSMIC: KIR2DL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243772ENST00000342376P43628
ENSG00000243772ENST00000342376E3NZD8

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
378744322024Association study between killer immunoglobulin-like receptor polymorphisms and susceptibility to COVID-19 disease: a systematic review and meta-analysis.1
378744322024Association study between killer immunoglobulin-like receptor polymorphisms and susceptibility to COVID-19 disease: a systematic review and meta-analysis.1
355374002022Clinical Impact of KIR2DS3 and KIR2DL3 Genes in Neuroblastoma Patients.1
355374002022Clinical Impact of KIR2DS3 and KIR2DL3 Genes in Neuroblastoma Patients.1
338462892021Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.17
349481232021Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.1
338462892021Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.17
349481232021Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.1
324223772020Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.6
324223772020Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.6
305209602019Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.6
306960532019Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.7
306988602019Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC.9
305209602019Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.6
306960532019Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.7

Citation

Dessen P

KIR2DL3 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/43615