FFAR1 (free fatty acid receptor 1)

2007-02-01 Affiliation

Identity

HGNC

FFAR1

LOCATION

19q13.12

LOCUSID

2864

ALIAS

FFA1R,GPCR40,GPR40

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2864
MIM: 603820
HGNC: 4498
Ensembl: ENSG00000126266

Variants:

dbSNP: 2864
ClinVar: 2864
TCGA: ENSG00000126266
COSMIC: FFAR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126266	ENST00000246553	O14842

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Insulin secretion	KEGG	hsa04911
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Incretin synthesis, secretion, and inactivation	REACTOME	R-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	REACTOME	R-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	REACTOME	R-HSA-400511
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Free fatty acid receptors	REACTOME	R-HSA-444209
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Free fatty acids regulate insulin secretion	REACTOME	R-HSA-400451
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME	R-HSA-434316

References

Pubmed ID	Year	Title	Citations
37914321	2023	[The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].	0
37914321	2023	[The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].	0
35061031	2022	GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.	4
35065200	2022	Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.	2
36309079	2022	Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.	5
35061031	2022	GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.	4
35065200	2022	Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.	2
36309079	2022	Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.	5
31487233	2020	Free Fatty Acid Receptors in Health and Disease.	321
32026734	2020	Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.	1
32121640	2020	Ginseng Gintonin Contains Ligands for GPR40 and GPR55.	5
31487233	2020	Free Fatty Acid Receptors in Health and Disease.	321
32026734	2020	Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.	1
32121640	2020	Ginseng Gintonin Contains Ligands for GPR40 and GPR55.	5
30597558	2019	Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis.	7

Citation

Dessen P

FFAR1 (free fatty acid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43619