LAPTM4B (lysosomal protein transmembrane 4 beta)

2007-02-01  

Identity

HGNC
LAPTM4B
LOCATION
8q22.1
LOCUSID
55353
ALIAS
LAPTM4beta,LC27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55353
MIM: 613296
HGNC: 13646
Ensembl: ENSG00000104341

Variants:

dbSNP: 55353
ClinVar: 55353
TCGA: ENSG00000104341
COSMIC: LAPTM4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104341ENST00000445593Q86VI4
ENSG00000104341ENST00000517924H0YBN1
ENSG00000104341ENST00000521545Q86VI4
ENSG00000104341ENST00000619747Q86VI4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383884842024LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy.0
383884842024LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy.0
367586822023LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.1
367586822023LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.1
358634792022Screening of four key genes in esophageal carcinoma based on TCGA and GEO data and verification of anti-proliferative effect of LAPTM4B knockdown in esophageal carcinoma cells invitro.0
358634792022Screening of four key genes in esophageal carcinoma based on TCGA and GEO data and verification of anti-proliferative effect of LAPTM4B knockdown in esophageal carcinoma cells invitro.0
331813242021LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.7
343932332021[Serum LAPTM4B-35 protein as a novel diagnostic marker for hepatocellular carcinoma].2
331813242021LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.7
343932332021[Serum LAPTM4B-35 protein as a novel diagnostic marker for hepatocellular carcinoma].2
326792282020Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover.4
330905222020Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.13
326792282020Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover.4
330905222020Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.13
307787482019Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma.3

Citation

Dessen P

LAPTM4B (lysosomal protein transmembrane 4 beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43622/js/favicon/gene-explorer/