MPO (myeloperoxidase)

2007-02-01  

Identity

HGNC
MPO
LOCATION
17q22
LOCUSID
4353
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4353
MIM: 606989
HGNC: 7218
Ensembl: ENSG00000005381

Variants:

dbSNP: 4353
ClinVar: 4353
TCGA: ENSG00000005381
COSMIC: MPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005381ENST00000225275P05164
ENSG00000005381ENST00000577220J3QSF7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443297AgranulocytosisDiseaseVariantAnnotationnot associatedPD27168101
PA445113NeutropeniaDiseaseVariantAnnotationnot associatedPD27168101
PA449061clozapineChemicalVariantAnnotationnot associatedPD27168101

References

Pubmed IDYearTitleCitations
354202912024The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.0
381645222024Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.1
385631712024[The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].0
354202912024The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.0
381645222024Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.1
385631712024[The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].0
363255942023Adult mixed phenotype acute leukemia (MPAL): B/myeloid MPAL(isoMPO) is distinct from other MPAL subtypes.1
367305082023Paediatric-onset generalized pustular psoriasis secondary to myeloperoxidase mutations.0
370589982023NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.6
372806122023Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation.2
372889592023Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.1
375694552023Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.1
376562542023Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.2
377767072023Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.0
379822292023Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.0

Citation

Dessen P

MPO (myeloperoxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43627