MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

2007-02-01  

Identity

HGNC
MAGI3
LOCATION
1p13.2
LOCUSID
260425
ALIAS
MAGI-3,dJ730K3.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 260425
MIM: 615943
HGNC: 29647
Ensembl: ENSG00000081026

Variants:

dbSNP: 260425
ClinVar: 260425
TCGA: ENSG00000081026
COSMIC: MAGI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081026ENST00000307546Q5TCQ9
ENSG00000081026ENST00000369611Q5TCQ9
ENSG00000081026ENST00000369615Q5TCQ9
ENSG00000081026ENST00000369617Q5TCQ9

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345108262021Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.4
345108262021Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.4
320809122020Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma.8
320809122020Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma.8
293623922018Premature polyadenylation of MAGI3 is associated with diminished N(6)-methyladenosine in its large internal exon.15
293623922018Premature polyadenylation of MAGI3 is associated with diminished N(6)-methyladenosine in its large internal exon.15
285454092017Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.13
285454092017Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.13
272058832016Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.15
272058832016Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.15
262487342015MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.13
264522192015MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.24
262487342015MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.13
264522192015MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.24
211343772011MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.35

Citation

Dessen P

MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43638/gene-fusions/img/gene-fusions-explorer/deep-insight-explorer/