Identity
HGNC
LOCATION
15q21.3
LOCUSID
ALIAS
HDLCQ12,HL,HTGL,LIPH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3990
MIM: 151670
HGNC: 6619
Ensembl: ENSG00000166035
Variants:
dbSNP: 3990
ClinVar: 3990
TCGA: ENSG00000166035
COSMIC: LIPC
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166035 | ENST00000299022 | P11150 |
| ENSG00000166035 | ENST00000356113 | P11150 |
| ENSG00000166035 | ENST00000414170 | E7EUJ1 |
| ENSG00000166035 | ENST00000433326 | E7EUK6 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449688 | fluvastatin | Chemical | ClinicalAnnotation | associated | PD | 16103896 | |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 16103896, 16115483 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 16103896 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37460425 | 2023 | [Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype]. | 0 |
| 37460425 | 2023 | [Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype]. | 0 |
| 35899625 | 2022 | Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia. | 3 |
| 36274132 | 2022 | Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. | 2 |
| 35899625 | 2022 | Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia. | 3 |
| 36274132 | 2022 | Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. | 2 |
| 32617858 | 2021 | The -514C>T polymorphism in the LIPC gene modifies type 2 diabetes risk through modulation of HDL-cholesterol levels in Mexicans. | 5 |
| 33499410 | 2021 | Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. | 4 |
| 33673789 | 2021 | Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study. | 0 |
| 32617858 | 2021 | The -514C>T polymorphism in the LIPC gene modifies type 2 diabetes risk through modulation of HDL-cholesterol levels in Mexicans. | 5 |
| 33499410 | 2021 | Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. | 4 |
| 33673789 | 2021 | Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study. | 0 |
| 31947886 | 2020 | The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations. | 10 |
| 32196671 | 2020 | Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil. | 1 |
| 32603185 | 2020 | Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase). | 2 |
Citation
Dessen P
LIPC (lipase C, hepatic type)
Atlas Genet Cytogenet Oncol Haematol. 2012-05-01
Online version: http://atlasgeneticsoncology.org/gene/43641/lipc
