NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)

2007-02-01  

Identity

HGNC
LOCATION
8q24.13
LOCUSID
ALIAS
C8orf36,MMS21,NSE2,ZMIZ7
FUSION GENES

Other Information

Locus ID:

NCBI: 286053
MIM: 617246
HGNC: 26513
Ensembl: ENSG00000156831

Variants:

dbSNP: 286053
ClinVar: 286053
TCGA: ENSG00000156831
COSMIC: NSMCE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156831ENST00000287437Q96MF7
ENSG00000156831ENST00000287437A0A024R9J6
ENSG00000156831ENST00000517315E5RFJ1
ENSG00000156831ENST00000517532E5RHW9
ENSG00000156831ENST00000518013E5RK09
ENSG00000156831ENST00000518146E5RG00
ENSG00000156831ENST00000519010A0A087WTZ8
ENSG00000156831ENST00000519712H0YB96
ENSG00000156831ENST00000520866A0A087WTZ8
ENSG00000156831ENST00000522563Q96MF7
ENSG00000156831ENST00000522563A0A024R9J6
ENSG00000156831ENST00000523741E5RIM1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362245762022NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer.5
362245762022NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer.5
305907222019A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest.17
307354912019Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage.16
305907222019A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest.17
307354912019Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage.16
277921892016Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.18
277921892016Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.18
251053642014Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.54
2524598420148q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.23
251053642014Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.54
2524598420148q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.23
227515012012Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.51
227515012012Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.51
215503422011The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.28

Citation

Dessen P

NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43647/meetings/css/lib/case-report-explorer/