Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3274
MIM: 142703
HGNC: 5183
Ensembl: ENSG00000113749
Variants:
dbSNP: 3274
ClinVar: 3274
TCGA: ENSG00000113749
COSMIC: HRH2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113749 | ENST00000231683 | P25021 |
| ENSG00000113749 | ENST00000377291 | P25021 |
| ENSG00000113749 | ENST00000624694 | A0A1B0GVZ0 |
| ENSG00000113749 | ENST00000636584 | A0A1B0GTK7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134890823 | PIK3R5 | Gene | Pathway | associated | |||
| PA175 | GNAS | Gene | Pathway | associated | |||
| PA33304 | PIK3C2A | Gene | Pathway | associated | |||
| PA33305 | PIK3C2B | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38418462 | 2024 | Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G(s) complex in nanodisc environment. | 0 |
| 38418462 | 2024 | Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G(s) complex in nanodisc environment. | 0 |
| 37470818 | 2023 | The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells. | 0 |
| 37470818 | 2023 | The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells. | 0 |
| 35776777 | 2022 | Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells. | 2 |
| 35776777 | 2022 | Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells. | 2 |
| 32385805 | 2021 | Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts. | 1 |
| 32385805 | 2021 | Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts. | 1 |
| 28728999 | 2018 | Histamine H2 receptor stimulation upregulates T(H)2 chemokine CCL17 production in human M2a macrophages. | 6 |
| 29191567 | 2018 | Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). | 7 |
| 28728999 | 2018 | Histamine H2 receptor stimulation upregulates T(H)2 chemokine CCL17 production in human M2a macrophages. | 6 |
| 29191567 | 2018 | Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). | 7 |
| 26475619 | 2016 | High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. | 5 |
| 26989676 | 2016 | Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure. | 6 |
| 27180173 | 2016 | Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors. | 9 |
Citation
Dessen P
HRH2 (histamine receptor H2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43658/hrh2
