PARG (poly(ADP-ribose) glycohydrolase)

2007-02-01  

Identity

HGNC
PARG
LOCATION
10q11.23
LOCUSID
8505
ALIAS
PARG99
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8505
MIM: 603501
HGNC: 8605
Ensembl: ENSG00000227345

Variants:

dbSNP: 8505
ClinVar: 8505
TCGA: ENSG00000227345
COSMIC: PARG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000227345ENST00000402038Q86W56
ENSG00000227345ENST00000610922A0A087WXI6
ENSG00000227345ENST00000614063A0A087WX07
ENSG00000227345ENST00000616448Q86W56

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
POLB-Dependent Long Patch Base Excision RepairREACTOMER-HSA-110362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374299652024PARG Promotes Esophagus Cancer Cell Metastasis by Activation of the Wnt/β-Catenin Pathway.0
374299652024PARG Promotes Esophagus Cancer Cell Metastasis by Activation of the Wnt/β-Catenin Pathway.0
378586782023O-GlcNAc has crosstalk with ADP-ribosylation via PARG.4
378586782023O-GlcNAc has crosstalk with ADP-ribosylation via PARG.4
360765932022Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes.2
360765932022Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes.2
336493092021Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).33
340198112021Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.44
336493092021Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).33
340198112021Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.44
324391632020PARG has a robust endo-glycohydrolase activity that releases protein-free poly(ADP-ribose) chains.13
330469072020Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.24
324391632020PARG has a robust endo-glycohydrolase activity that releases protein-free poly(ADP-ribose) chains.13
330469072020Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.24
304593552019Oncogenic activity of poly (ADP-ribose) glycohydrolase.19

Citation

Dessen P

PARG (poly(ADP-ribose) glycohydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43674