CALCA (calcitonin related polypeptide alpha)

2007-02-01  

Identity

HGNC
CALCA
LOCATION
11p15.2
LOCUSID
796
ALIAS
CALC1,CGRP,CGRP-I,CGRP-alpha,CGRP1,CT,KC,PCT

Other Information

Locus ID:

NCBI: 796
MIM: 114130
HGNC: 1437
Ensembl: ENSG00000110680

Variants:

dbSNP: 796
ClinVar: 796
TCGA: ENSG00000110680
COSMIC: CALCA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110680ENST00000331587P01258
ENSG00000110680ENST00000361010P06881
ENSG00000110680ENST00000396372P01258
ENSG00000110680ENST00000469608P01258
ENSG00000110680ENST00000486207P06881

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164754825botulinum toxin type aChemicalClinicalAnnotationassociatedPD
PA165108779Migraine NOSDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
370134322024Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis.0
378529382024The role of calcitonin gene-related peptide and substance P in the pathogenesis of dialysis headache.0
381649812024Deciphering the influence of Y12L and N17H substitutions on the conformation and oligomerization of human calcitonin.0
381933502024CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.0
382564232024CGRP Antagonism and Ketogenic Diet in the Treatment of Migraine.0
383089392024Calcitonin gene-related peptide (CGRP) levels in peripheral blood in patients with idiopathic intracranial hypertension and migraine.1
384230112024Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs.2
384479302024Is calcitonin gene-related peptide (CGRP) the missing link in food histamine-induced migraine? A review of functional gut-to-trigeminovascular system connections.0
385014912024Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations.0
385229292024[PATHOGENIC MEMORY THE2 CELLS INDUCE CONJUNCTIVAL ITCH VIA IL-33-ST2-CGRP AXIS].0
385839452024Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP.0
386276232024Calcitonin gene-related peptide: a possible biomarker in migraine patients with patent foramen ovale.0
387509172024Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis.0
370134322024Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis.0
378529382024The role of calcitonin gene-related peptide and substance P in the pathogenesis of dialysis headache.0

Citation

Dessen P

CALCA (calcitonin related polypeptide alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43682