Identity
HGNC
LOCATION
2q32.2
LOCUSID
ALIAS
CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6772
MIM: 600555
HGNC: 11362
Ensembl: ENSG00000115415
Variants:
dbSNP: 6772
ClinVar: 6772
TCGA: ENSG00000115415
COSMIC: STAT1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134992438 | CAMK1D | Gene | Pathway | associated | |||
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA24685 | AKT2 | Gene | Pathway | associated | |||
| PA24686 | AKT3 | Gene | Pathway | associated | |||
| PA248 | NFKB1 | Gene | Pathway | associated | |||
| PA26048 | CAMK1 | Gene | Pathway | associated | |||
| PA26049 | CAMK1G | Gene | Pathway | associated | |||
| PA27749 | ELK1 | Gene | Pathway | associated | |||
| PA28212 | FOS | Gene | Pathway | associated | |||
| PA283 | MAPK8 | Gene | Pathway | associated | |||
| PA296 | RELA | Gene | Pathway | associated | |||
| PA29988 | JAK1 | Gene | Pathway | associated | |||
| PA30006 | JUN | Gene | Pathway | associated | |||
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA30622 | MAPK3 | Gene | Pathway | associated | |||
| PA31353 | MYC | Gene | Pathway | associated | |||
| PA31600 | NFKB2 | Gene | Pathway | associated | |||
| PA33285 | PIAS1 | Gene | Pathway | associated | 26111151 | ||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA36042 | SP1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36185 | STAT4 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated | |||
| PA90 | CAMK2A | Gene | Pathway | associated | |||
| PA91 | CAMK2B | Gene | Pathway | associated | |||
| PA92 | CAMK2D | Gene | Pathway | associated | |||
| PA93 | CAMK2G | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38047403 | 2024 | LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis. | 1 |
| 38084635 | 2024 | Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research. | 2 |
| 38092960 | 2024 | RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression. | 4 |
| 38166970 | 2024 | AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma. | 1 |
| 38246175 | 2024 | [Knockdown of interferon-γ inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis]. | 0 |
| 38351096 | 2024 | HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression. | 0 |
| 38410923 | 2024 | hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy. | 1 |
| 38509096 | 2024 | Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. | 2 |
| 38640981 | 2024 | STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma. | 0 |
| 38706215 | 2024 | USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1. | 0 |
| 38758476 | 2024 | Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations. | 0 |
| 38797155 | 2024 | KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma. | 0 |
| 38812060 | 2024 | Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma. | 1 |
| 38869352 | 2024 | AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease. | 0 |
| 38047403 | 2024 | LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis. | 1 |
Citation
Dessen P
STAT1 (signal transducer and activator of transcription 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/437/stat1
