DNASE1L3 (deoxyribonuclease 1 like 3)

2007-02-01  

Identity

HGNC
LOCATION
3p14.3
LOCUSID
ALIAS
DHP2,DNAS1L3,LSD,SLEB16
FUSION GENES

Other Information

Locus ID:

NCBI: 1776
MIM: 602244
HGNC: 2959
Ensembl: ENSG00000163687

Variants:

dbSNP: 1776
ClinVar: 1776
TCGA: ENSG00000163687
COSMIC: DNASE1L3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163687ENST00000394549Q13609
ENSG00000163687ENST00000394549A0A024R365
ENSG00000163687ENST00000460422C9J0L2
ENSG00000163687ENST00000461914C9J9N0
ENSG00000163687ENST00000477209H7C4R7
ENSG00000163687ENST00000483681A0A0A0MT68
ENSG00000163687ENST00000486455Q13609

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381081192024Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.0
382461762024[Decreased DNase1L3 secretion and associated antibodies induce impaired degradation of NETs in patients with sporadic SLE].0
387448392024Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.0
381081192024Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.0
382461762024[Decreased DNase1L3 secretion and associated antibodies induce impaired degradation of NETs in patients with sporadic SLE].0
387448392024Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.0
367080112023Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant.0
367080112023Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant.0
356709852022DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling.4
357481062022DNASE1L3 inhibits proliferation, invasion and metastasis of hepatocellular carcinoma by interacting with β-catenin to promote its ubiquitin degradation pathway.6
363270922022DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2.2
356709852022DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling.4
357481062022DNASE1L3 inhibits proliferation, invasion and metastasis of hepatocellular carcinoma by interacting with β-catenin to promote its ubiquitin degradation pathway.6
363270922022DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2.2
330355692021A deoxyribonuclease 1-like 3 genetic variant associates with asthma exacerbations.3

Citation

Dessen P

DNASE1L3 (deoxyribonuclease 1 like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43705/dnase1l3