SEMA3A (semaphorin 3A)

2007-02-01  

Identity

HGNC
SEMA3A
LOCATION
7q21.11
LOCUSID
10371
ALIAS
COLL1,HH16,Hsema-I,Hsema-III,SEMA1,SEMAD,SEMAIII,SEMAL,SemD,coll-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10371
MIM: 603961
HGNC: 10723
Ensembl: ENSG00000075213

Variants:

dbSNP: 10371
ClinVar: 10371
TCGA: ENSG00000075213
COSMIC: SEMA3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075213ENST00000265362Q14563
ENSG00000075213ENST00000420047C9J9C4
ENSG00000075213ENST00000424555C9JD25
ENSG00000075213ENST00000436949Q14563
ENSG00000075213ENST00000448879A0A0C4DG50

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375332402024Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1.2
379998232024Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy.0
382383002024Sema3A secreted by sensory nerve induces bone formation under mechanical loads.4
382634162024Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes.0
386093902024Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8(+) T cells.1
388578302024Role of Semaphorin 3A in common psychiatric illnesses such as schizophrenia, depression, and anxiety.0
375332402024Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1.2
379998232024Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy.0
382383002024Sema3A secreted by sensory nerve induces bone formation under mechanical loads.4
382634162024Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes.0
386093902024Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8(+) T cells.1
388578302024Role of Semaphorin 3A in common psychiatric illnesses such as schizophrenia, depression, and anxiety.0
364702092023CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.3
366607962023Semaphorin 3A inhibits tumor progression via the downregulation of Lin28B in ovarian cancer.1
364702092023CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.3

Citation

Dessen P

SEMA3A (semaphorin 3A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43720/sema3a-(semaphorin-3a)