CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

2007-02-01 Affiliation

Identity

HGNC

CYP3A43

LOCATION

7q22.1

LOCUSID

64816

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64816
MIM: 606534
HGNC: 17450
Ensembl: ENSG00000021461

Variants:

dbSNP: 64816
ClinVar: 64816
TCGA: ENSG00000021461
COSMIC: CYP3A43

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000021461	ENST00000222382	Q9HB55
ENSG00000021461	ENST00000312017	Q9HB55
ENSG00000021461	ENST00000342499	F8W6L8
ENSG00000021461	ENST00000354829	Q9HB55
ENSG00000021461	ENST00000415413	E9PDL8
ENSG00000021461	ENST00000417625	Q9HB55
ENSG00000021461	ENST00000433277	E7EMH4
ENSG00000021461	ENST00000434806	Q9HB55
ENSG00000021461	ENST00000436834	E9PG90
ENSG00000021461	ENST00000444905	C9JA26
ENSG00000021461	ENST00000631161	Q9HB50

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
Miscellaneous substrates	REACTOME	R-HSA-211958

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PK		25935875
PA165374673	ticagrelor	Chemical	ClinicalAnnotation	associated	PK		25935875
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PK	PD	21519338, 24595013
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PK	PD	21519338, 24595013

References

Pubmed ID	Year	Title	Citations
36613552	2022	Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance.	4
36613552	2022	Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance.	4
32301865	2020	Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.	7
32301865	2020	Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.	7
28673024	2018	Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A Polymorphisms.	3
28673024	2018	Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A Polymorphisms.	3
26585945	2016	Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.	5
26585945	2016	Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.	5
25150845	2015	Genetic variation in CYP3A43 is associated with response to antipsychotic medication.	14
25150845	2015	Genetic variation in CYP3A43 is associated with response to antipsychotic medication.	14
24595013	2014	No influence of CYP3A43 rs472660G> A on steady-state serum olanzapine concentrations in white psychiatric patients.	1
24595013	2014	No influence of CYP3A43 rs472660G> A on steady-state serum olanzapine concentrations in white psychiatric patients.	1
20529763	2010	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	8
20715157	2010	The frameshift polymorphism CYP3A43_74_delA is associated with poor differentiation of breast tumors.	3
21081028	2010	Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.	7

Citation

Dessen P

CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43751/meetings/haematological-explorer/css/lib/dataTables.bootstrap.min.css