CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

2007-02-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 64816
MIM: 606534
HGNC: 17450
Ensembl: ENSG00000021461

Variants:

dbSNP: 64816
ClinVar: 64816
TCGA: ENSG00000021461
COSMIC: CYP3A43

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021461ENST00000222382Q9HB55
ENSG00000021461ENST00000312017Q9HB55
ENSG00000021461ENST00000342499F8W6L8
ENSG00000021461ENST00000354829Q9HB55
ENSG00000021461ENST00000415413E9PDL8
ENSG00000021461ENST00000417625Q9HB55
ENSG00000021461ENST00000433277E7EMH4
ENSG00000021461ENST00000434806Q9HB55
ENSG00000021461ENST00000436834E9PG90
ENSG00000021461ENST00000444905C9JA26
ENSG00000021461ENST00000631161Q9HB50

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPK25935875
PA165374673ticagrelorChemicalClinicalAnnotationassociatedPK25935875
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPKPD21519338, 24595013
PA450688olanzapineChemicalClinicalAnnotationassociatedPKPD21519338, 24595013

References

Pubmed IDYearTitleCitations
366135522022Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance.4
366135522022Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance.4
323018652020Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.7
323018652020Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.7
286730242018Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A Polymorphisms.3
286730242018Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A Polymorphisms.3
265859452016Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.5
265859452016Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.5
251508452015Genetic variation in CYP3A43 is associated with response to antipsychotic medication.14
251508452015Genetic variation in CYP3A43 is associated with response to antipsychotic medication.14
245950132014No influence of CYP3A43 rs472660G> A on steady-state serum olanzapine concentrations in white psychiatric patients.1
245950132014No influence of CYP3A43 rs472660G> A on steady-state serum olanzapine concentrations in white psychiatric patients.1
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
207151572010The frameshift polymorphism CYP3A43_74_delA is associated with poor differentiation of breast tumors.3
210810282010Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.7

Citation

Dessen P

CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43751/meetings/haematological-explorer/css/template-nav.css