CACYBP (calcyclin binding protein)

2007-02-01  

Identity

HGNC
CACYBP
LOCATION
1q25.1
LOCUSID
27101
ALIAS
GIG5,PNAS-107,S100A6BP,SIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27101
MIM: 606186
HGNC: 30423
Ensembl: ENSG00000116161

Variants:

dbSNP: 27101
ClinVar: 27101
TCGA: ENSG00000116161
COSMIC: CACYBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116161ENST00000367679Q9HB71
ENSG00000116161ENST00000367679A0A024R904
ENSG00000116161ENST00000405362Q9HB71
ENSG00000116161ENST00000406752Q9HB71
ENSG00000116161ENST00000426793B2ZWH1
ENSG00000116161ENST00000613570Q9HB71

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365765892023CACYBP knockdown inhibits progression of prostate cancer via p53.2
371561242023Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.0
373735092023The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.1
365765892023CACYBP knockdown inhibits progression of prostate cancer via p53.2
371561242023Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.0
373735092023The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.1
350872012022Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.0
350872012022Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.0
328804692021CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.1
345305742021[CacyBP promotes the proliferation and invasion of non-small cell lung cancer].4
345916482021Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.2
328804692021CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.1
345305742021[CacyBP promotes the proliferation and invasion of non-small cell lung cancer].4
345916482021Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.2
330499982020HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation.4

Citation

Dessen P

CACYBP (calcyclin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43780/gene-fusions/favicon/js/web-card-gene.js