HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)





Pubmed IDLast YearTitleAuthors
207163402010Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.Boukakis G et al
178980772007Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.Cammas A et al
127994332003Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.Campillos M et al
127169752003Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance.Chen H et al
294844232018High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.Chen Y et al
179509492008The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element.Cheunim T et al
200108082010HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.David CJ et al
30727061988Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.Dreyfuss G et al
241665032014microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1.Fujiya M et al
271498422016Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.Giannakis M et al
183910212008Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.Goina E et al
175584162007The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a.Guil S et al
207959512010Functional diversity of the hnRNPs: past, present and perspectives.Han SP et al
113134742001Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription.Hay DC et al
253388722015Loss of hnRNPA1 in ALS spinal cord motor neurons with TDP-43-positive inclusions.Honda H et al
120606562002Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor.Hutchison S et al
270665602015Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.Izumi R et al
172896612007Molecular composition of IMP1 ribonucleoprotein granules.Jønson L et al
240651002013hnRNP A1: the Swiss army knife of gene expression.Jean-Philippe J et al
234554232013Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.Kim HJ et al
279843732017HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection: Comparison With Conventional Tumor Markers.Kim YJ et al
109729772000Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter.Lau JS et al
276942602016Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.Liu Q et al
265815082016Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase.Liu X et al
261513922015CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer.Loh TJ et al
225361162012Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.Martínez-Salas E et al
154486912004Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.Mendell JT et al
206398842010Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.Michlewski G et al
115859132001Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA.Mili S et al
298725002018Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.Otsuka K et al
13713311992Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.Piñol-Roma S et al
253243062014hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.Roy R et al
229221912012The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.Singh AK et al
221321542011hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.Talukdar I et al
230520362013Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.Teng Y et al
157038182005Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.Ushigome M et al
156710342005Regulation of gamma-fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein A1.Xia H et al
293674662018Mutations in Hnrnpa1 cause congenital heart defects.Yu Z et al
166037172006hnRNP A1 associates with telomere ends and stimulates telomerase activity.Zhang QS et al
228213762013Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma.Zhou ZJ et al

Other Information

Locus ID:

NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486


dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486


Gene IDTranscript IDUniprot

Expression (GTEx)



PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected


Pubmed IDYearTitleCitations
234554232013Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.460
200108082010HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.391
264123072015Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.342
175584162007The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a.232
201338372010The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.176
117795092001Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins.150
213996252011TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.139
206398842010Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.128
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
193393522009hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication.75


Dessen P

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: