GDI2 (GDP dissociation inhibitor 2)

2007-02-01  

Identity

HGNC
GDI2
LOCATION
10p15.1
LOCUSID
2665
ALIAS
HEL-S-46e,RABGDIB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2665
MIM: 600767
HGNC: 4227
Ensembl: ENSG00000057608

Variants:

dbSNP: 2665
ClinVar: 2665
TCGA: ENSG00000057608
COSMIC: GDI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000057608ENST00000380127Q5SX90
ENSG00000057608ENST00000380181P50395
ENSG00000057608ENST00000380191P50395
ENSG00000057608ENST00000380191Q6IAT1
ENSG00000057608ENST00000418688Q5SX86
ENSG00000057608ENST00000447751Q5SX91
ENSG00000057608ENST00000456041Q5SX87
ENSG00000057608ENST00000608581V9GYF8
ENSG00000057608ENST00000609712V9GYJ7

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340515752021GDI2 is a target of paclitaxel that affects tumorigenesis of prostate cancer via the p75NTR signaling pathway.6
345568142021ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling.16
348943982021GDI2 is a novel diagnostic and prognostic biomarker in hepatocellular carcinoma.9
340515752021GDI2 is a target of paclitaxel that affects tumorigenesis of prostate cancer via the p75NTR signaling pathway.6
345568142021ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling.16
348943982021GDI2 is a novel diagnostic and prognostic biomarker in hepatocellular carcinoma.9
329454582020MicroRNA‑15b‑5p exerts its tumor repressive role via targeting GDI2: A novel insight into the pathogenesis of thyroid carcinoma.3
329454582020MicroRNA‑15b‑5p exerts its tumor repressive role via targeting GDI2: A novel insight into the pathogenesis of thyroid carcinoma.3
175072992007Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.34
175072992007Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.34
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
117717572001Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.6
117717572001Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.6

Citation

Dessen P

GDI2 (GDP dissociation inhibitor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43809/deep-insight-explorer/cancer-prone-explorer/